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However, these effects are neither linear nor monotonic as we see strong reversion towards autocratic institutional preferences in low self-expressive, survival dominated societies.
Instead, several of these mutations were associated with reversion towards consensus B like variants, supporting the notion that some of these mutations may lower viral fitness [21], [33], [34], [35].
During the course of serial transmission, their virulence is expected to increase by genetic reversion towards 1∶200 (for type 1) or 1∶1000 (for types 2 and 3), although the rate at which this occurs is unknown.
To determine if rapid reversion towards the B subtype consensus was evident in the any of the regions under study here, we tracked mutational patterns in all positions where the transmitted form of the virus differed from the B subtype consensus amino acid.
Therefore, RA-conditioned MoDC exposed to an inflamed microenvironment showed no evidence of reversion towards a proinflammatory phenotype.
Reversion towards group M consensus occurs at a roughly constant rate throughout the observation time (5 8 years).
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A large fraction of all substitutions are reversions towards the global HIV-1 consensus sequence, and these reversions steadily accumulate throughout infection.
But the fact that all optimisation criteria agree on reconstructions involving several reversions towards heteroecy suggests that we can have a high level of confidence in this scenario.
Reversions towards the ancestral HIV-1 sequence are observed throughout infection and account for almost one third of all sequence changes.
DOI: http://dx.doi.org/10.7554/eLife.11282.021 Of all changes accumulated by the viral populations, 30 ± 2.5% are reversions towards group M consensus (mean and standard deviation of patient bootstraps after 4 7 years).
The metabolic patterns on week 8 and week 9 showed the reversion tendency towards the week 0 pre-dose state with the treatment of YGJD.
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