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Amino acid prodrugs meet the criteria of aqueous solubility, chemical stability and quantitative reversion to parent molecule, and thus are suitable for in vivo preclinical evaluation.
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The final objective in this work was to evaluate the potential mutagenicity of breakdown products using the Salmonella (Ames) mutagenicity assay and by measuring the extent of reversion to the parent compound under conditions simulating the human stomach, both of which were minimal.
In conclusion, alanyl- and lysyl-amide prodrugs of 2- 4-amino-3-methylphenyl benzothiazoles undergo reversion to their parent amine.
Herein, reversion of prodrugs to parent molecule and selective antitumour activity in vitro has been described.
This is followed by a doubling in DNA content which results in reversion to the tetraploid glucocorticoid resistant state of the parent line CCRF/CEM.
Panic is reversion to instinct.
But then came a reversion to form, and Iraq.
This is undoubtedly a reversion to "primitive" behaviour.
In a weird reversion to a kind of Calvinist fatalism, he now claimed that disability was an inherited punishment for the vice of the parents, and that blind children were better off left in the care of their families.
Reexposure to oxygen causes immediate reversion to the discoidal form.
He called for a reversion to the original April timetable.
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