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High temperature reversion tests have revealed a state of pre-existing molecular orientation in extruded polyethylene sheet.
In Figure 5 and most of the reversion tests described below, the number of viable cells plated is used to normalize results of the reversion test.
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The suspected Coccicioides colony was evaluated through the in vivo reversion test (9 ).
The reversion of test results at the 1st and 6th months of therapy compared to baseline were statistically significant (p = 0.023 and p<0.001 at 1 and 6 months, respectively).
For example, in the histidine reversion bacterial mutagenicity tests (Ames test), 95 out of 102 assays showed no evidence of mutagenicity.
These cells are thought to closely correlate with antigen load, driven by the burden of M.tuberculosis.[5], [6], [31], [32] Therefore it is not surprising that we found significant qualitative and quantitative test reversion with effective therapy.
One would expect such a phenomenon to occur most frequently where there is a high rate of BCG vaccination at birth and intense exposure to environmental mycobacteria, as these are particularly associated with early skin test reversion [4], [5].
There was only one QFN test reversion and it occurred in the IPT arm.
Poor reproducibility of the assay is a more likely explanation than true reversions since the tests were performed within short periods.
Of the 22 clinical isolates of M. tuberculosis during smear reversion, drug susceptibility testing was repeated for 14, which revealed additional drug resistance in two isolates.
Lee et al. reported that QFT-IT test reversion occurred in 41.9 % of the subjects and IFN-gamma levels decreased in almost all subjects after LTBI treatment [ 16].
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