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The balance between escape and reversion results in association between specific escape mutations and the HLA types of the hosts (Kawashima et al., 2009; Palmer et al., 2013).
The bias towards reversion results in a two- to three-fold reduction of the long-term evolutionary rate of HIV, a trend that is reinforced by selection during transmission (Carlson et al., 2014; Sagar et al., 2009).
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In this case, the recA reversion resulted in the largest loss of resistance with an approximately 50-fold decrease in IR resistance relative to CB2000.
The use of IFN-γ tests in the follow-up of negative TST HCWs requires further studies which analyze the meaning of the conversions and reversions results.
This product-to-parent reversion mechanism results in unique diurnal cycling and substantial regeneration of TBA metabolites at rates that are strongly temperature- and pH-dependent.
Although faster reversion dynamics result in reduced slopes, increased onward transmission among drug-naive patients results in steeper slopes.
However, phenotypic reversion can result from changes that restore a different amino acid with properties identical to the original.
Molecular characterization of the 9 revertants showed that all the reversion events resulted from deletions with microhomologies ranging from 1 to 11 bp in size (see Additional file 1).
The reversion of test results at the 1st and 6th months of therapy compared to baseline were statistically significant (p = 0.023 and p<0.001 at 1 and 6 months, respectively).
For the reversion study, our results substantiate the study by Ou et al. [ 5] who reported that methylated genes could be restored by 5-azaC.
Such reversion events can result in removal of the integrated construct including the drug selectable marker, resulting in low levels of contamination of mutant parasite populations with wild type parasites [51].
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