Established mechanisms of resistance to imatinib are discussed, as are novel therapeutic approaches to improving drug responsiveness by reversing development of imatinib resistance in patients.
In a resolution of the 65th General Assembly of the UN, it is clearly stated that "the financial and economic crisis... has reversed development gains in many developing countries and threatens to seriously undermine the achievement of the Millennium Development Goals".
These factors could reverse development gains, it says.
"Reverse development" may be as important for the next 60 years, as north-south development has been for the past 60.
"Reverse development" is what we need, and we should set up a northern based agency staffed by southerners to help build our own capacity to meet the SDGs.
DfID has previously been warned that its strategy in fragile states will take time to bear fruit, as renewed fighting and corruption can reverse development gains.
Conclusion: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.
"The negative consequences of climate change are already disrupting these countries' development trajectories, with potential to reverse development trends by mid-century," the expert said.
The world body estimates the conflict has reversed development gains in Syria by 35 years, with half its people now living in poverty.
It is threatening to reverse development gains as it destroys livelihoods and infrastructure, devastates crops, leaves millions hungry, and undoes people's efforts to climb out of poverty.
And just as a lack of development can cause and exacerbate conflicts and natural disasters, so disasters and conflicts can halt and even reverse development progress.
