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"The North Koreans took a showy but easily reversible step and then we didn't notice it when they reversed it in an unexpected way," Lewis said.
However, caspase-8 inhibition by the peptidomimetics goes through a rapid equilibrium step, a slow-binding reversible step, and an extremely slow inactivation step.
Tegobuvir could not be seen to interact with NS5B at all while filibuvir interacted in a single reversible step (except at low temperatures) and VX-222 in two serial steps, interpreted as an induced fit mechanism.
It was found that the Kamal's model and a mechanistic model comprising an activation reversible step followed by a propagation step (Mauri et al., 1997 [4]) were capable to well describe all the experimental data.
At a tungsten electrode, Nb3Cl8 is reduced to metallic niobium through two consecutive electrochemical steps: a first reversible step involving one electron charge transfer and a second rather irreversible step implying two electrons number exchange and yielding to metallic niobium.
An analytical solution is presented for the concentration profiles inside a catalyst particle with uniform activity for a parallel-consecutive reaction scheme containing a reversible step and in which the reactions are all of the first order.
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The three-stage "minimal" kinetic scheme with first and second reversible steps of substrate binding and with following irreversible peptide cleavage step adequately described experimental data.
We represent irreversible reactions as limits of reversible steps and obtain the principle of detailed balance for complex mechanisms with some irreversible elementary processes.
GpmA, pgmI, gapA, fbaA, and fbaB genes, encoding enzymes that catalyze reversible steps in gluconeogenesis and glycolysis, were also induced in the wild-type strain at the time of aggregation (Figure 4A, Figure 5C).
The steps in the derivation involve only thermodynamically reversible steps.
The carefully regulated exonization of Alu exons enables the evolutionary path to be taken in small reversible steps.
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