Suggestions(1)
Exact(4)
The inhibitor of miR-101 (targeting ATM but not DNAPKcs) or miR-101* (targeting DNA-PKcs but not ATM) partially reversed the sensitivity of the cells over-expressed with miR-101, and combining the two inhibitors almost completely reversed the cell sensitivity (Figure 3C), confirming that the sensitization effects are derived from both strands of miR-101, which target both DNA-PKcs and ATM.
Similarly, 5-aminoimidazole-4-carboxamide ribonucleoside reversed the sensitivity of Akt-expressing glioblastoma cells to glucose deprivation by activation of AMPK [202].
Along the same line, overexpression of miRNA-214 in RS NSCLC cells reversed the sensitivity of the cells through the regulation of p38MAPK pathway.
Inhibition of TG2 by siRNA, antisense RNA or small-molecule inhibitors reversed the sensitivity of cancer cells to chemotherapeutic drugs and attenuated their invasion, both in vitro and in animal models [ 6, 12- 16] 16][ 17].
Similar(56)
We confirm that over-expression of Rad60 can reverse the sensitivity of smc6-X to MMS, and has a slight effect on the response to HU (Figure 6B).
Moreover, SC_Sec61β1 and SC_Sec61β2 also fully reversed the SDS sensitivity of the S. pombe Δsbh1 strain (Figure 4C).
Similarly, feminization of corazonin neurons in males bearing the NaChBac element partially reversed the stress sensitivity exhibited in males expressing the NaChBac element and tempered the phenotypes associated with male corazonin ork expression.
Reintroduction of the MSH2 gene reversed the decreased sensitivity.
Verapamil almost completely reversed the gemcitabine sensitivity to the level of the parental SW1573 cells.
Remarkably, pretreatment with NAC significantly reversed the cellular sensitivity to arsenite in the two HR mutants (XRCC3−/− and RAD54−/−) (Table 4).
Initial identification of desmosdumotin B showed that co-incubation of verapamil reversed the collateral sensitivity of KB-VIN cells, suggesting that functional P-gp was necessary for activity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com