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Lithium and valproate reduced tau phosphorylation and prevented reversed aspects of tauopathy in animal models [ 113] but did not show cognitive improvement in clinical trials with AD patients [ 114].
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Gene therapy approaches for DMD using recombinant adeno-associated viral (rAAV) vectors have the potential to halt dystrophic progression and reverse aspects of the muscle pathophysiology.
Dietary inorganic nitrate was recently shown to reverse aspects of the metabolic syndrome in rodents by as yet incompletely defined mechanisms.
These results using the TCNS suggested that ranirestat could reverse aspects of the pathophysiology of DSP and emphasized the importance of a sensitive clinical scoring system as the outcome measure in therapeutic trials.
Since inhibition of SPT reversed some aspects of cellular dysfunction in our studies, our findings suggest that inhibition of the initial step of sphingolipid synthesis may provide a useful therapeutic strategy to pursue in these diseases.
Resistance exercise can reverse specific aspects of the gene expression changes in aging to more youthful levels (Melov et al., 2007).
The important and novel finding is that resistance exercise training reverses many aspects of the aging transcriptome signature.
This study provides evidence that CF-containing foods can be effective in reversing certain aspects of age-related cognitive decline.
Emerging evidence suggests that testosterone therapy may be able to reverse some aspects of metabolic syndrome[ 4].
The rabbit models suggest that prolonged disc distraction might reverse some aspects of the compression-induced degeneration with better results at the L3/L4 level [ 47– 51].
Testing and quarantine of suspected animal cases, especially domestic pets, is much more humane nearby with benefits of eliciting the zoonotic and reverse zoonotic aspects of the infection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com