Sentence examples for reverse the defect from inspiring English sources

Over-expression of dnPKA mRNA, a downstream of Shh, could reverse the defect induced by Mtmr8 deficient.

Given the adipogenic effects of IGF-2 in T37i cells and the induction by PRL of IGF-2 expression, we next determined if incubation with exogenous IGF-2 could reverse the defect in brown adipocyte differentiation observed in PRLR KO cells.

Consistent with this possibility, Cbl-b and Vav1 double knockout mice have been studied by Krawczyk et al[29], who reported that Cbl-b inactivation did not reverse the defects in thymic development in Vav1-/ mice but did reverse defective proliferation of peripheral T cells.

In support of the idea that these functions are independent of the role of Spt10 as an activator of histone gene transcription, suppressors of the spt10 Δ growth defect do not reverse the defects in histone gene transcription.

The concentration used in three sets of experiments failed to produce visible effects in control embryos (minimum 30 per experiment), but was able to strikingly reverse the defects induced by nipblb-MO injection (minimum 30 per experiment).

Importantly, the LGP2-deficient cells were complemented by expression of human LGP2, reversing the defect by restoring greater CXCL10 mRNA accumulation (Figure 2a).

In Richardson ground squirrels, cisapride reverses the defect in gallbladder contractility, enhances bile salt secretion and lowers cholesterol saturation [ 11].

Adoptive transfer of normal marrow cells into the CD44-deficient mice reversed the defect in apoptotic cell clearance and improved survival.

Importantly, re-constitution of p110α PI3 kinase expression under conditions of TBL1 inhibition completely reversed the defect in cellular proliferation (Fig 3D), demonstrating that p110α PI3 kinase indeed acts downstream of TBL1.

Growth of the fei1 fei2 mutant in the presence of α-aminoisobutyric acid (AIB), which is a structural analogue of ACC that blocks ACO activity by acting as a competitive inhibitor of the ACC substrate, completely suppressed the root phenotype of fei1 fei2 and also reversed the defect in cellulose biosynthesis in fei1 fei2 (Xu et al. 2008).

The deletion of Cbl thus reversed the defects in phosphorylation of ERKs and PLC- γ1 in Vav1-/ thymocytes and enables Cbl-/-Vav1-/ thymocytes to efficiently generate TCR-activated signaling events that are normally dependent upon Vav1.