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Therefore ERT should be started as soon as symptoms/signs occur in an effort to stabilize (or even reverse) pathology.
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Reversing pathology may have particular clinical relevance as most AD studies involve patients that are at an advanced pathological stage.
Previous studies have shown that transgenic manipulation which removes PrPc expression from scrapie-affected neurons reverses pathology and putatively eliminates infection of neurons [39].
The implied possibility of reversing pathology, in contrast to slowing decline, is an exciting one but needs further evaluation.
We showed that Ifnb gene therapy reversed pathology in a familial PD model, by promoting autophagy and α-syn clearance, which preserved DA neurons and associated neurologic deficit.
Additionally, anti-IL-1β blocking antibodies have been shown to reverse lung pathology in steroid-resistant models of severe asthma53.
We tested the hypothesis that an AAV9 vector encoding hGAA would result in retrograde transport and restore neuromuscular junction integrity and reverse axonal pathology in Pompe disease.
Models that reflect the pathogenesis of disease will be crucial in enhancing our understanding, not only of the immunopathology, but also in the design and application of therapeutics, which prevent or reverse disease pathology.
ART reduces immune activation and restores immune cell populations but may not reverse HIV pathology.
These mice showed clearance of peripherin IF accumulations suggesting that gigaxonin gene transfer can reverse the pathology.
Resveratrol may be prospective to reverse the pathology by enhancing BH4 biosynthesis, reducing OS production, and increasing ROS scavenging [ 109].
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