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Contrast medium exposure activates the reverse mode of NCX1 expressed in renal tubular epithelial cells; NCX reversely extrudes Na+ for Ca2+ influx and results in increased intracellular Ca2+.
"We're in reverse mode".
Using lens of reverse mode autodiff, with examples and Jupyter notebooks in Python and TensorFlow.
This can be done in either one of two ways: the forward mode or the reverse mode of automatic differentiation.
We conclude that in the subplate GAT-2/3 operates in reverse mode.
Interestingly, a metabolic stimulus, such as glutamate, could induce the reverse mode of NCXm, as a consequence of glutamate-induced Na+ influx through excitatory amino acid transporters31.
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Reverse-mode automatic differentiation is of particular interest for large-scale optimization problems.
Because the system is fully compatible with Autograd, it allows forward- and reverse-mode automatic differentiation of Python functions to arbitrary order.
Hence, this increase in fura-2 ratio represented Ca2+ influx mediated by reverse-mode NCKX4 activity.
When measured at a similar driving force KBR inhibited > 50% of reverse-mode INCX (Fig. 7 B ).
Local, TRPC3-mediated Na+ loading at rest (holding potential) is expected to promote reverse-mode currents upon depolarization.
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