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Nobiletin (NOB) exhibits a wide spectrum of beneficial biological properties including anti-inflammatory, antioxidant, anti-carcinogenic actions and contributes to reverse learning impairment in Alzheimer's disease rat.
We examined the effect of long-term rTMS on reverse learning performance in ephrin-A2 -/- and wildtype mice.
To overcome this problem, data were divided into three blocks for each subject, with one third of total days training included in each block, reflecting early, middle, and late stages of the reverse learning phase.
Although the current study provides important insights into the nature of reverse learning that can occur with global health partnerships, our findings should be viewed in light of several limitations.
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Boosting the level of a brain chemical reverses learning impairments in a mouse model of Down syndrome, researchers report.
Moreover, the use of the NO donors, sGC stimulators, and cGMP-analogs reverses learning and memory impairment through cGK activation, in part by reestablishing the enhancement of the transcription factor cAMP-responsive element-binding protein (CREB), which is phosphorylated during long term potentiation [21].
For example, the 5-HT1A receptor agonist 8-OH-DPAT reversed learning deficits induced by scopolamine and MK-801 in an autoshaping learning task.
For example, L-DOPS restored the balance of the brain inflammatory system, facilitated microglial migration and Aβ phagocytosis, and reversed learning deficits in dsp-4 lesioned APP transgenic mice [ 36], and also partially rescued spatial memory deficits in the DBH-/-, APP/PS1 double-mutant mice [ 39].
Previous studies have reported that activation of M1 potentiates NMDAR currents in hippocampal pyramidal cells, increases excitatory postsynaptic currents in medial prefrontal cortical neurons, improves fear conditioning, and reverses deficits in discrimination reversal learning observed in a mouse model of Alzheimer's disease.
Previous DTI studies on CD boys attributed higher FA and lower RD values in the UF to deficiencies of reversal learning abilities, which refers to learning to "reverse" responses that were previously rewarded but later punished [ 18– 20].
The authors concluded that 7,8-DHF might potentially be used for the treatment of reversing learning and extinction deficits associated with psychopathology, and furthermore, might serve as a useful adjuvant treatment for anxiety disorders that are responsive to behavioral treatments using the extinction process.
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CEO of Professional Science Editing for Scientists @ prosciediting.com