Sentence examples for reverse developmental from inspiring English sources

The reason for the reverse developmental regulation of Cld-9 and Cld-11 remains however to be clarified.

However, successful pharmacological interventions to reverse developmental defects are likely to entail using agents that are themselves teratogenic.

The program involves direct intervention with a child to address his or her identified needs, reverse developmental delays, and reduce the impact of risk factors and adverse events.

In particular, leptin administration during the neonatal period reverses developmental programming of metabolic disorders in the rat [ 102].

Ectopic expression of transgenic TCR complexes cannot reverse the developmental block in CD2 C3 thymocytes demonstrating that failed expression of TCR complexes does not explain the developmental defects caused by loss of Rho function [18].

Furthermore, by mapping the output of each gene to the inputs of other genes, it is possible to reverse engineer developmental circuits and even whole networks.

This study and one other randomized controlled trial suggest that iron therapy can reverse the developmental effects after at least two months of therapy [ 13- 15].

The ability of reduced GRK2 activity to reverse a developmental phenotype associated with constitutive desensitization supports efforts to genetically or pharmacologically target this kinase in diseases involving biased GPCR signaling.

However, this action of NT-3 required reversing the developmental loss of NMDA receptor activity due to Mg2+ block by enhancing expression of the NMDA-receptor 2d (Nregulatoryatory subunit in motoneurons using Herpes simplex virus (HSV-1) amplicon-mediated delivery of NR2d (Arvanian et al., 2004).

In a second experiment we extended the treatment period to seven days, since injection of IL-2 for only two days may be too short to fully reverse the observed developmental defect in the thymus in IκBα-SR Tg mice.

Since oligodendrocytes produce the brain's supply of cholesterol and since progression of neurodegeneration in AD follows the reverse pattern of developmental myelination [ 7], oligodendrocyte dysfunction has been suggested as an early event in AD progression [ 18], and has been clearly linked to aging [ 50].