However, the absence of an effect of the D2 receptor antagonist led these authors to conjecture that other striatal sub-regions may be implicated in reversal performance.
In this study, we had asked whether Ccnd2−/− mice would show learning deficits related to task acquisition and reversal performance in the water maze as we had found in our previous study using a different method to ablate adult neurogenesis.
In Phase 2, although both groups showed a decrement in performance, indicating problems with reversal learning, TE subjects significantly outperformed TI subjects.
Hence, while we observed complementary responses in vmPFC (decreased responses on reversal trials) and caudate (increased responses on reversal trials), the responses in vmPFC more closely paralleled the observed differences in performance, with more accurate responses on placebo with salient reversal cues, and a similar difference in the profile of neural activation in vmPFC.
Discrimination and reversal learning performance did not run in families to any detectable degree.
It is notable that damage to the NAc (present study, [39,8,38]) does not disrupt reversal learning performance but D2 stimulation in the NAc core does [20].
The region moved left politically circa 2000, partially turning its back on the Washington Consensus — and there has been a dramatic reversal in inequality trends: What about economic performance?
CHTHET-6OHDA did not differ in performance across IDS IV to IDS VI or in comparison with the reversal (P>0.5).
Conversely, the declined in performance at pH ranges 9 7 and 5 3 could be linked to +ve and −ve species-induced charge reversal, respectively.
Blackstone also posted $124.1 million in negative revenue, as management fees were more than offset by the reversal of performance fees triggered by declining asset values.
