Consistent down-regulation of critical inflammatory genes in ETS- and doubly OVA-exposed mice was confirmed through qRT-PCR, revealing down-regulation of 17 asthma-related and/or inflammatory genes (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2, Il4, Il6, Il10, Il13, Il1b, Tnfa).
(a) RT-PCR analysis of T3 transgenic seeds of MO6-196, as compared to the internal control β tubulin reveals down-regulation in the transcript level of MIPS (b) Expression levels of MIPS as determined by Quantitative real time PCR.
Our data revealed down-regulation of phospholamban, an endogenous inhibitor of SERCA, in APP/PS1 mouse hearts.
Analysis of the defense related genes revealed down-regulation for several of them at 1 dpi indicating that M. loti is recognized as a beneficial microbe.
Transcriptional profiling of eed1Δ during infection of oral tissue revealed down-regulation of hyphal associated genes including UME6, encoding another key transcriptional factor.
Overall, GO category analysis of thymus tissue transcriptome revealed down-regulation of important processes in thymocyte development and up-regulation of inflammatory and wound healing responses.
Gene expression profiling and qRT-PCR analyses revealed down-regulation of the key pluripotency markers POU5F1 and NANOG and up-regulation of the trophoblast markers CDX2, KRT7, HAND1, FOXF1, GATA3, and ID2 (Figure 3B).
Transcriptome analysis revealed down-regulation of GATA4, an important regulator of cardiomyocyte survival.
Studies of NPC biopsies revealed down-regulation of HLA class I APM expression.
Moreover, both Northern blotting and microarray tests revealed down-regulation of miR-275 in both sexes during this process.
Relative abundance values were log-scaled to reveal down-regulated proteins with the same significance as up-regulated.
