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The mtDNA depletion in MEFs and embryonic tissues was revealed to be functionally significant, as it resulted in reduction of steady state levels of mtDNA-encoded proteins, multiple respiratory chain deficiencies, and cellular respiration defects.
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The application of our method to another MFS-MDR transporter EmrD of E. coli further reveals that residues which are shown to be functionally critical were found to have high CRES score and could be matched with critical residues of CaMdr1p.
Considering that genes with co-occurring mutations tend to be functionally related, as revealed above, this result suggests that genes in a densely interacted local network structure (i.e., genes with many mutual interactions) tend to be more robust against errors (e.g., mutations) and have smaller lethality than those in a sparsely interacted local network structure.
Our results revealed that deletions of functionally related genes caused similar morphologic phenotypes, enabling loci to be functionally assigned to a specific cellular pathway [8].
MHC DRA was found to be functionally monomorphic in the 32 individuals screened; whereas DRB exon 2 revealed 66 unique alleles among the 246 individuals screened.
They have to be functionally equivalent campuses.
A similar number have been found to be "functionally obsolete".
And the Medicare bill restricts Medicare from declaring drugs to be functionally equivalent in the future.
I was still too fat to be functionally gay.
By comparing epigenomes, with their developmental end-points from different phyla we should be able to reveal what is functionally common and what is different.
Together, these observations imply that (i) driver-network genes have functional importance specific to the TNBC subtype and (ii) integrated analysis was able to reveal candidates that were functionally more important than what could be obtained using the strongest candidates from differential expression analysis alone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com