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Promoter analysis revealed the activation of GLI-1 promoter activity in RANKL-overexpressing cells, suggesting that activation of GLI-1 is due to RANKL.
Microarray findings revealed the activation of gene groups that function in smooth muscle differentiation, signaling pathways, extracellular modeling and cell proliferation.
Further analysis revealed the activation of both apoptotic pathways via modulation of the proteins involved in the extrinsic and intrinsic pathways with an increase in TNF-R1, Fas-L and Bax levels and a reduction in Bcl-2 expression.
This preliminary contrast revealed the activation of areas known to be involved in attentional and linguistic processing [40], such as posterior parietal, dorsal cingulate, the dorsolateral prefrontal cortex (DLPFC) extending superiorly towards the precentral sulcus (frontal eye fields, FEFs), and the left ventrolateral prefrontal cortex/anterior insula (VLPFC/AI).
Instead we revealed the activation of an attentional network primarily shown in experiments on attention: the visual top-down attentional network (or dorsal system) [24] in which the FEF and the superior parietal cortex constitute key regions (see Fig. 2A and Table S2, conjunction analysis).
Taken together, our investigation of gene expression in tea revealed the activation of related metabolic pathways compared to oil tea.
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Natural antibodies to HSP60 are detectable in the serum of healthy humans [48], [49] and mice [50]; the IgG isotype of these antibodies reveals the activation of helper HSP60-specific T cells.
The translocation of p65 NF-κb from cytoplasm to nuclear reveals the activation of NF-κb.
Despite the potential of pitfalls inherent to the use of the microarray technology (review in [ 27]), gene module analysis of the myometrial transcriptome reveals the activation of precise signaling pathways, some of which may have been under evaluated.
Despite the potential of multiple pitfalls inherent to the use of the microarray technology, gene module analysis of the myometrial transcriptome reveals the activation of precise signaling pathways, some of which may have been under evaluated.
This study is the first to reveal the activation of DENV infected monocytes based on induction of iNOS both in vivo and in vitro, as well as the susceptibility of DENV-1 to a NO production.
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