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While [68Ga]HA-DOTATATE and [68Ga]DOTATATE had shown similar target- and non-target uptake in patients, biodistribution studies in mice at 1 h post injection (n = 5) revealed slightly increased non-specific uptake of [68Ga]HA-DOTATATE in the blood, liver, and intestines (0.7 ± 0.3, 1.0 ± 0.2, and 4.0 ± 0.7 %iD/g vs 0.3 ± 0.1, 0.5 ± 0.1, and 2.7 ± 0.8 %iD/g for [68Ga]DOTATATE).
The results of ROT measurements revealed slightly increased internal conductivity and decreased membrane conductance of HMC during the first 12 hr of exposure to crocidolite.
In line with this finding, stratification for different types of mutations and mutational subgroups generally revealed slightly increased HRs (for details see Table 3).
The temporary production of acetate by the SS type is consistent with previous SS-FS coculture experiments, which revealed slightly increased acetate concentrations towards the end of the SS exponential growth phase (Spencer et al., 2007).
Restricting analyses to patients who did not receive blood transfusions revealed slightly increased MRRs (anemic COPD patients: adjusted 30-day MRR 3.7 [95% CI 1.9 7.0] and adjusted 90-day MRR 3.2 [95% CI 1.7 5.9]).
A logistic regression assessing the relationship between a cancer diagnosis during the look back period and treatment group revealed slightly increased odds of glargine-only use among patients with prevalent cancer (compared with no prevalent cancer) (odds ratio 1.06 [95% CI 1.00 1.12]; P = 0.043).
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Evaluation of thermal balance during application of both devices revealed slightly increasing body temperature under MARS application (+0.3 °C, −0.15 to +0.75) compared with SPAD treatment (−0.1 °C, −0.55 to +0.35).
In seven tumour-free patients, PET revealed slightly increasing but homogeneous FET uptake surrounding the resection cavity with a peak up to 18 months following RIT (TUmax/BG 2.07±0.25) but stable or decreasing values during further follow-up (last follow-up: TUmax/BG 1.63±0.22).
aChest radiograph reveals slightly increased transparency of the left lung and thin linear translucency contouring the left border of the lower mediastinum.
Corresponding axial (c) and coronal (d) CECT images reveal slightly increased enhancement of the right submandibular gland (arrows), reticulated aspect of subcutaneous fatty tissue (asterisk) and thickening of the right platysma muscle due to sialadenitis with phlegmon.
In contrast, the irradiated cells of hypersensitive cancer patients revealed a slightly increased Rad50 level of 1.1±0.1, which was 1.3 times higher than in irradiated control cells (0.8±0.2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com