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Gene set enrichment analysis revealed pathways enriched in our histopathological classification significantly overlapped with the four molecular subtypes: mesenchymal, immunoreactive, proliferative, and differentiated (P < 0.0001, respectively).
Microgenomic analyses identified novel transcriptional markers and revealed pathways of muscle fiber plasticity.
This study revealed pathways specifically up- or down-regulated at relapse that may be used as targets for drug development in pediatric ependymomas.
GSEA also revealed pathways in which the loss of NMD in fetal liver cells resulted in an up-regulated expression of genes involved in mRNA processing ("mRNA processing reactome"), including splicing factors (Figure 3C,D) which have previously been shown to be auto-regulated via NMD [9], [10], [13], [29].
Figure 5 presents the identified regulatory miRNA-mRNA network for all 3 revealed pathways.
Second, the analysis revealed pathways clearly related to inflammation mainly in the lung and brain.
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In three of five patients, multi-region analysis revealed marked ITH, whereas results revealed pathway convergence upon mTOR pathway activation [11, 14].
Detecting novel splice junctions in the cancer transcriptome may reveal pathways driving tumorigenic events.
These reveal pathways of vulnerability and provide targets for rational drug design.
This study aimed to evaluate the effect of fenofibrate and gemfibrozil on inflammation in macrophages and reveal pathways these agents may affect.
In the first lesson all students measured the arm span of one student, revealing pathways students follow in developing understanding of variation and linear measurement (related to research question 1).
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