Data integration enables the identification of general trends, including common pathways, revealing master regulatory hubs activated or deactivated across different tissue types [ 77].
This approach can be particularly useful to reveal master regulatory or hub genes, since hub genes of modules are expected to play a critical role in regulating the expression of several dozens of other genes in the module and can in fact be used as biomarkers.
There is a third character, of course: the sculptor who, it seems, has revealed his master's true nature, and, moreover, must be responsible for the telling second half of the inscription: "Look on my works, ye mighty, and despair!" The full irony of this is brought home by the final image of the boundless sands, stretching as far as the eye can see.
I'd like to have been at the first meeting when he revealed his master plan.
Salary site PayScale revealed the master's degrees leading to jobs with high pay at the early-career (zero to five years' experience) and mid-career (10 or more years' experience) stages.
The Bravotv.com tour revealed a master bedroom featuring a custom 11-by-12-foot 11-by-12-foot 11-by-12-foot 11-by-12-foot fireplace, perhaps from the collection of royal Franz Archduke Ferdinand of World War I fame.
Functional and regulatory network analyses based on a knowledge database revealed a master network of PIP co-modulated genes, including many interconnecting oncogenes and tumor suppressor genes, half of which were detected as differentially expressed through high-precision measurements.
This revealed 7 master regulatory proteins and its associated networks and encompassed 114 proteins of which 34 were disease regulated.
Further, systems biology analysis revealed key master regulators in cells transfected with control siRNAs including the cytokine, Interleukin (IL -1, transcrIL -1n factranscriptioning Protein (GATA)-4 and the methylation enzyme, Enhancer ofactore homoloGATA(EZH-2) a cytokine with an apical role in initiating the inflammatory response.
