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Analyses revealed copy number accumulation and hypomethylation of both clusters.
The hybridization profile of the Sagui element revealed copy variations among the different M. fijiensis isolates.
Genome-wide screening using Agilent 44K aCGH microarrays revealed copy number alterations in 100% (91/91).
Oncomine search revealed copy number loss and reduced mRNA levels in various bladder cancer stages (Supplementary Figure S2).
Genome-wide screening using microarrays showed large genomic heterogeneity in MM cases and revealed copy number alterations in 100% (91/91) of samples.
FISH analysis revealed copy number heterogeneity within a UC: cancer cells showing two signals and those showing one signal were both observed in T4.
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Microarrays assess thousands of transcripts, or millions of single nucleotide polymorphisms (SNPs), and next-generation sequencing (NGS) can reveal copy number and genetic aberrations at base pair resolution.
These four probes were also capable of revealing copy gains between CIN1 and CIN2 histological categories with a percent change range of 11.0% to 19.0%.
Whole genome sequencing can, in addition to identifying variation in coding regions, reveal copy number variation (CNV) and chromosomal rearrangements at high resolution.
This technical approach is also evidently able to reveal copy number aberrations, as we encountered a 47, XXY neonate in our sample cohort.
The mean copy number for this probe was found to be 1.32 thereby revealing copy losses as opposed to gain in the cancer category, which was expected and is concordant with the previously obtained results.
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