Early studies using in vitro cell culture model systems revealed a contribution of Rac1 to cell cycle regulation [11] and in Ras-mediated transformation [12], [13].
As discussed above, certain conditions, such as ripoptosome formation in the absence of IAPs also revealed a contribution of RIPK1 kinase activity to apoptosis, suggesting that the in vivo efficacy of Nec-1 may rely on its ability to target both types of cell death.
Our maps of the peatland distribution (Figs. 1 and 2) reveal a contribution of 83.3, 4.0, and 12.7% from the boreal (and polar), temperate, and tropical zone, respectively, to the total peatland area.
Trace element concentrations in the Roñanzas peat bog record reveal a contribution of natural processes but the influence of anthropogenic factors predominates in the last two millenniums, particularly aerosol deposition linked to mining and industrial activities in northern Spain.
A possibility to reveal a contribution of ionospheric plasma density oscillations at different altitudes into the total TEC fluctuations may help to identify a responsible mechanism.
Hence, our results are the first to reveal a contribution of impaired signalling through the MAVS pathway to SLE pathogenesis.
Further focus on the SNPs identified in this study may reveal a contribution of these SNPs in the etiology of the disease.
Thus, age-specific gene expression profiling can provide information on processes that may be related to ovarian/oocyte aging and possibly reveal a contribution of altered gene expression to decreased fertility.
The results shown in the present study reveal a contribution of phosphoinositides to the recruitment of STIM1, since puncta formation was inhibited under conditions that would deplete PtdIns4 P, PtdIns(4,5) P2 and PtdIns 3,4,5) PtdIns 3,4,5
It is possible that further study of TRPA1 in A-fibres, many of which are cold-responsive at very low stimulus temperatures (Simone & Kajander, 1997), may reveal a contribution of this class of fibres to the behavioural changes seen in inflammation (Obata et al., 2005).
While these results are mostly in line with previous results on CB1 function in adult neurogenesis (reviewed in [ 13]), they also go beyond what was known since our data elucidate the time-course of this action and reveal a contribution of CB1 to activity-dependent regulation.
