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Upon receiving an external cue, these systems generate a transient response that quickly returns to basal levels even if the stimulus persists.
After some time, tyrosine phosphorylated IRS downregulates or returns to basal levels, while the serine phosphorylation of IRS remains elevated (Figure 3A).
This increase is transient as expression returns to basal levels 3 days after alloantigen exposure, and is not observed in CD25−CD4+ cells.
The plasma TNF maximal peak in rats is supposed to occur two hours after LPS treatment, while after six hours the level of TNF returns to basal values [14].
In contrast with these results, previous reports by Rochefort and others [27] indicated that increased GC survival following olfactory enrichment is transitory and returns to basal level once animals are placed back to standard conditions, suggesting that GC survival can still be modulated by sensory experience.
Analysis of heat stress induced activation of the pathway reveals that the activation is a transient process in that the activity of the pathway returns to basal level following a short activation period despite the persistence of the heat stress [11], [22].
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The second peak was detectable at 120 min post-exposure and returned to basal level by 240 min.
Phosphorylation only returned to basal levels between 8 and 24h.
A final measurement was performed once patients spontaneously returned to basal BT.
Then hepatocyte DNA synthesis returned to basal level at 3 days.
A final measurement was performed when patients spontaneously returned to basal BT.
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