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Rodgers talked of reloading for next season, with all the injured players returning to the nucleus of a team that is built for the long run.
This is not surprising as a reduction of TDP-43 returning to the nucleus can be compensated by the self-regulation mechanism that will increase TDP-43 production as necessary.
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These four viral transcripts undergo additional processing and go on to form progeny virions that are released from the cell or returned to the nucleus and re-cycled to produce even more copies.
Also, this mechanism could allow cargo-free CRM1 to return to the nucleus without an intervening release into the bulk cytoplasm.
This implies that the rate of protein synthesis is on the order of ~0.047 molecules/s; in other words, each ERF1 molecule is synthesized and returned to the nucleus in ~21.3 s.
With a core nucleus returning to the links in 2013, the Laguna Beach High girls' golf team could be primed for a successful year.
Returning to the mouse model, our lab sought other cell types that might be able to reprogram a somatic nucleus.
Hence, when the second pulse of high Akt activity ends (at t = 1260) and FOXO returns to the nucleus, the transcription level (Figure 6B) is at first also less than half what it was before the Akt pulse.
They could directly measure for themselves how fast Whi5 returns to the nucleus after inhibition of CDK1.
PER and CRY proteins then accumulate in the cytoplasm and, after a lag period, return to the nucleus to inhibit their own transcription as well as the expression of other genes activated by the CLOCK-BMAL1 heterodimer (9, 10).
In this case, however, it should be noted that mutating the NLS is just a way to increase the amount of TDP-43 production through its autoregulation process (6, 7) by increasing the amount of this protein that is made by the cell and exported to the cytoplasm with minimal return to the nucleus.
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