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Denosumab clinical trial data show a complete reversibility of both BTM and BMD effect 6 months after administration of the 60 mg dose and a return to responsiveness with repeat administration.
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Here, we return to the definition of responsiveness as future-oriented responsibility, which obliges a 'receptive attitude towards needs and desires of others, before deciding what to do' (Pellizzoni, 2004).
Feedback loops, primarily mediated through glucocorticoid receptors (GRs) in the PVN and pituitary, regulate responsiveness of the HPA axis ensuring a return to a homeostatic balance when it is no longer challenged (Fig. 1).
The syllables I return and return to.
Return to the fridge.
may return to America.
Return to the Sibyl.
Return to side position.
Return to the Jarl.
Return to the window.
Then return to bed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com