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Transfecting vinculin −/− cells with the vinculin tail fragment, which harbors the actin and paxillin binding sites, showed a return of cell stiffness to the levels of F9 wild-type cells.
These results suggest that HSC homeostasis is primarily maintained by endogenous stem cells in the bone marrow, and not from the return of stem cells from the circulation.
Many studies support the increase in NK cell numbers in the circulation during progressive exercise, as well the fast return of NK cells towards preexercise levels during subsequent recovery [ 22, 23].
The hypersensitivity disappeared after return of the cells to the permissive temperature.
This same substitution reappeared in virus populations isolated at later timepoints, after the return of CD8+ cells.
One method of augmenting CTL responses is to expand autologous antigen-specific CTLs ex vivo followed by the return of these cells into the affected individual.
Will the return of B cells signal a recrudescence of clinical disease?
Clinical relapse was associated with rises in autoantibodies rather than only with return of B cells [ 28].
Return of the cells to the normal growth temperature of 37 degrees C leads to a partial restoration of enzyme activity.
However, return of these cells to oestrogen-containing medium for more than 8 weeks resulted in the re-expression of ER mRNA and protein.
Interestingly, fragmentation was reversible, as indicated by the recovery of elongated morphology upon return of the cells to normal growth temperature (Fig. 1B).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com