In some cases, high impact research provided retrospective support and rationale for existing health promotion programs, such as the NSW Rural Hearing Conservation Program.
In the present retrospective analysis the rationale for intraperitoneal irinotecan was response to systemic irinotecan-based chemotherapy in seven patients, disease progression under oxaliplatin-based systemic chemotherapy in three and oxaliplatin-associated peripheral polyneuropathy ≥ grade 3 in two patients.
We used protocols of randomised controlled trials and corresponding publications included in a retrospective cohort study; the rationale and design have been described elsewhere.
Antiplatelet therapy is common in this population and has been associated with increased morbidity and mortality after head injury, but the evidence has been based mainly on pathophysiologic rationales and retrospective analyses with limited patient numbers [ 2].
Current management protocols for the care of the deceased donor before organ procurement are based on physiological rationale, experiential reasoning, and retrospective studies without rigorous testing.
Current management protocols for the care of the organ donor before organ procurement are based on physiological rationale, experiential reasoning, and retrospective studies without the benefit of rigorous testing [3].
Current management protocols for the care of the organ donor before organ procurement are based on physiological rationale, experiential reasoning, and retrospective studies without the benefit of rigorous testing [ 3].
First, the retrospective design precluded a complete understanding of the rationale for test ordering.
However, only low-level evidence is available to support this rationale [ 19], as most studies were retrospective and had limited statistical power.
In conclusion, these results, in the context of other recently reported retrospective studies and adjuvant trials, provide support for the rationale of using adjuvant trastuzumab in this subgroup of patients, who are typically classified as having very good prognosis.
