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Methods to minimize and correct for head motion by restraint, fast imaging, and retrospective image registration are typically combined but do not completely solve the problem, particularly for specific patient populations.
The most reliable technique in detection of cervical lymph node metastases was PET imaging (AUC: 0.95), followed by side-by-side analysis and retrospective image fusion technique (AUC: 0.941), which however, was not significantly better then the MRI (AUC 0.935; p > 0.05).
For retrospective image quantification, age-specific 3D-printed phantoms were manufactured and calibration measurements were performed.
The research comprised four steps: (1) phantom experiments for retrospective image quantification by depth- and size-dependent attenuation correction, (2) Estimation of patient-specific time-integrated activity coefficients (TIACs), (3) Calculation of the absorbed and effective doses, and (4) Risk assessment.
Physiologic noise correction was performed using RETROICOR (retrospective image correction).
No significant benefit of retrospective image fusion was seen compared with side-by-side analysis.
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Retrospective images were obtained by identifying entries in theatre lists, and notes were then obtained from the hospital records library.
Second, prospective in vivo research is better than retrospective images or specimen dissections.
This pilot study was designed to test the feasibility of the project using retrospective images before a prospective study begins.
Retrospective SPECT/CT image interpretation was performed 14 weeks after conclusion of the accrual period by randomly assigning images to either of two attending physicians, each with >15 years of experience in clinical nuclear medicine and radiology.
Gating (prospective or retrospective, if image acquisition is acquired simultaneously or processed post-acquisition) is already implemented in most of the preclinical in vivo imaging systems using specialised software.
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