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The latter could establish feedback loops that are important in determining retroactivity.
Retroactivity in cellular biology appears when an upstream promoter experiences feedback from the activation of downstream promoters, as observed experimentally in the nitrogen assimilation control system of E. coli [ 13].
In order to attenuate the effect of retroactivity on a system dynamics, we propose to design insulation devices based on a feedback mechanism inspired by the design of amplifiers in electronics.
Here we propose that perturbations (e.g., from an inhibitor) that occur downstream of a shared component can also induce cross-talk effects without any explicit feedback connections via the following mechanism: the information travels upstream from the site of the perturbation through retroactivity, reaches the common component and then is delivered to the parallel pathway.
Retroactivity is hugely important".
"On principle, I have problems with retroactivity," she said.
But others expressed concern about the lack of retroactivity.
The main objection to the bill was its retroactivity provision.
But, Mr. Meister said, "the overarching issue is retroactivity".
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