Unfortunately, in the rush for adoption, unrealistic effective dates and unwarranted retroactivity provisions were included.
One cause of context dependence, similar to what found in many engineering systems, is retroactivity, that is, the effect of loads applied on a module by downstream systems.
Our investigation considered only the effect of retroactivity and targeted inhibitors on the individual motifs we studied in the absence of genetic and/or other regulatory relationships.
Our results indicate that within physiologically and therapeutically relevant ranges for all parameters, a targeted inhibitor can naturally induce an off-target effect via retroactivity.
This finding led us to hypothesize that a targeted inhibitor can produce upstream off-target effects via retroactivity that can propagate elsewhere in the signaling network.
Our results indicate that within physiologically and therapeutically relevant ranges for all parameters, a targeted inhibitor can naturally induce a steady state off-target effect via retroactivity.
If a bill is enacted without a retroactive provision, or if retroactivity in this case is found to be unconstitutional, the grandparent would have saved $2,172,500.
This effect has been termed "retroactivity".
However, due to sequestration of molecular messengers during interactions and other effects, collectively referred to as retroactivity, real biochemical systems do not exhibit perfect modularity.
We hypothesize that targeted therapies such as kinase inhibitors can produce off-target effects as a consequence of retroactivity alone.
