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Thus here the retroactivity effect of pathway B on pathway A is weak, when compared to that of pathway A on B. Now we consider the effect of simultaneous step changes provided to A and B. We find that the concentrations of both complexes initially rise, but that eventually the concentration of the complex of the low affinity component is depleted by the retroactivity effect.
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By contrast, phosphotransfer systems, and single and double phosphorylation cycles that transmit signals from a substrate, are unable to mitigate retroactivity effects, even when cascaded, and hence are not well suited for unidirectional information transmission.
Moreover, some of the factors affecting system modularity have been found, such as DNA sequences that might enhance or decrease transcriptional activity when placed upstream or downstream of promoters [ 6, 15] or retroactivity effects due to the presence of DNA binding sites in interconnected modules [ 8, 21].
While full retroactivity was unanimously approved, the Commission said it would take a "measured" approach and make retroactivity effective on November 1, 2015, instead of in 2014.
After the Miller case, three states entirely eliminated juvenile life without parole, joining six other states that had already banned the sentence, and lawsuits on the retroactivity issue are pending in several states.
One cause of context dependence, similar to what found in many engineering systems, is retroactivity, that is, the effect of loads applied on a module by downstream systems.
In order to attenuate the effect of retroactivity on a system dynamics, we propose to design insulation devices based on a feedback mechanism inspired by the design of amplifiers in electronics.
Our investigation considered only the effect of retroactivity and targeted inhibitors on the individual motifs we studied in the absence of genetic and/or other regulatory relationships.
Our results indicate that within physiologically and therapeutically relevant ranges for all parameters, a targeted inhibitor can naturally induce an off-target effect via retroactivity.
Our results indicate that within physiologically and therapeutically relevant ranges for all parameters, a targeted inhibitor can naturally induce a steady state off-target effect via retroactivity.
While we may have been too conservative in the estimation of the ranges defined in Table 1, this finding supports the position that a targeted inhibitor can naturally induce an off-target effect via retroactivity over a range of physiologically relevant conditions.
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