If a participant discontinued treatment prematurely, or for all participants rescued during the 6-month on-treatment period (EDITION 2 and 3 only), time windows were applied to retrieve assessments performed at premature end-of-treatment and pre-rescue visits for the MMRM analyses.
Six of the 51 full-text copies of studies that were retrieved for assessment were excluded because they were technology assessments or systemic reviews/current concept papers (15, 22, 24, 41, 73, 74).
The titles and abstracts of studies were examined independently by two reviewers (RFB, EK) and potentially relevant studies were retrieved for assessment for inclusion in the review.
Those clearly not meeting the inclusion and exclusion criteria were removed and full reviews thought to be of relevance were retrieved for assessment against the inclusion and exclusion criteria.
For the review of interventions in all settings, over 150,000 hits were screened: 5000 were considered potentially relevant papers and full text articles of 863 were retrieved for assessment.
Papers meeting the full inclusion criteria were retrieved for detailed assessment.
Implant sites were allowed to heal for 2 weeks, after which specimens were retrieved for morphometric assessment by using backscatter scanning electron microscopy and the Bioquant Image Analyzer.
Full articles were retrieved for further assessment.
One hundred ninety-six full-text articles were retrieved for further assessment.
All remaining publications will be retrieved for further assessment.
