These data suggest that therapies which degrade the ability of drug cues to retrieve a response-drug expectancy should be superior to Pavlovian cue exposure therapies.
Broadly, AlgaePath can be used to retrieve a cellular response in a pathway under a specific condition.
Even Slackbot, the tool built into the popular work messaging platform Slack, doesn't need you to type "Hey Slackbot" in order to retrieve a pre-programmed response.
M4 KO mice took significantly longer to retrieve a reward following correct responses on the last day of training (wild-type = 1.6 ± 0.2 s; M4 KO = 2.2 ± 0.12 s; t18 = 2.47, p < 0.05), which is most likely not an effect of reward salience as previous studies have shown an increased motivation to respond for liquid reinforcers in M4 KO mice.
The implication of these studies is that drug stimuli will most readily retrieve a representation of the response-drug contingency by virtue of possessing spatial, affective, perceptual or semantic elements in common with the drug outcome, and such 'compatible' stimuli will be most hazardous in producing relapse.
The claim that external discriminative stimuli prime responding by retrieving a gestalt response-outcome expectancy is supported by a diverse variety of findings.
Of these, 253 were retrieved, giving a response rate of 90%.
650 copies of the questionnaire in two large and influential hospitals in southern Taiwan were distributed, among which 532 valid copies were retrieved with a response rate of 81.8%.
A total of 700 copies of questionnaires from two authoritative southern Taiwan medical centers providing the electronic medical record system and the online appointment system service were distributed, among which 590 valid copies were retrieved with a response rate of 84.3%.
Participants were instructed to retrieve a memory of a specific event in response to each word.
When an individual is requested to retrieve an autobiographical memory in response to a cue word, a retrieval model is first created against which knowledge is accessed, evaluated and elaborated for further search.
