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Two-thirds of the stimuli (256: 128 negative, 128 neutral) were reserved for encoding and to serve as "old" stimuli during retrieval tests, with separate subsets used for Test 1 and Test 2 (64 negative and 64 neutral per test).
RE was inactivated before or immediately after training or before the probe trial of retrieval tests.
During the immediate and delayed retrieval tests, subjects viewed previously seen ("old") and novel ("new") stimuli presented in the center of the screen (as opposed to lateralized; Fig. 1C).
Moreover, the relative proportion of items within each semantic category was kept identical across encoding and retrieval tests, between negative and neutral items, and between old and new items.
Seventy-one healthy volunteers underwent a protocol consisting of memory encoding and both immediate and delayed retrieval, with retrieval tests organized around a ~12 h retention interval containing wakefulness or sleep (Fig. 1A).
Simulations of the Canister Retrieval Tests experiment, using both the finite element solver Code_Bright and the analytical model show that the models agree well with the experimental data.
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Wild-type daughters born to mutant mothers were impaired in their ability to retrieve pups to a nest in a retrieval test.
Why retrieval testing helps is still unknown.
(b) Freezing behavior during the second extinction retrieval test.
Supplementary Figure 3 Silencing extinction-tagged neurons impairs extinction retrieval in second extinction retrieval test.
Second extinction retrieval test occurred 1 d after the alternate context test.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com