Hypoxia selective uptake and retention (= trapping) of [18F]FAZA occurs only under hypoxic conditions.
Both astrocytes and pericytes have been shown to support barrier function via tight junction retention and reduction of endothelial cell death under hypoxic conditions [ 6, 11– 11].
Cellular trapping of [18F]FAZA into the Caki-1 and MCF-7 cells was increased approximately eightfold to tenfold under hypoxic conditions, confirming increased cellular retention of [18F]FAZA under hypoxic conditions.
The retention and cellular uptake of ruthenium complex is enhanced under hypoxic conditions and its LD50 decreases to 8 μM for A549 cell line.
The tissue pO2 was not measured directly, but rather was estimated by measuring the retention of [F]fluoroisonidazole, a lipophilic 2-nitroimidazole derivative that is irreversibly bound to intracellular macromolecules under hypoxic, but not normoxic, conditions.
99mTc-SD32 showed sufficient accumulation and good retention in hypoxic cellshowed
Pseudomonas aeruginosa Proteome under Hypoxic Stress Conditions Mimicking the Cystic Fibrosis Lung.
ERRγ has been shown to be upregulated and to increase several key hypoxic-response genes, such PDK4, LDHA, and VEGF, under hypoxic conditions36.
Under hypoxic conditions, the HIF pathway acts as a key transcriptional regulator of tumor-induced angiogenesis33.
The activation of HIF-1α is required for cell survival under hypoxic conditions.
