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In each case, however, the hydropathic nature of these sites has been retained, which may reflect retention of functions for these sites.
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Whether this leads to retention of function of duplicated genes or to functional diversification either at the level of gene expression or protein function remains to be determined.
The extent to which thermostability influences the location of protein fragmentation sites that allow retention of function is not known.
Fibronectin was deposited and its distribution and structure investigated and retention of function (ability to promote cell adhesion) on return to liquid environment is shown.
Here, I present a sophisticated strategy for constructing a multifunctional microparticle for medical applications using multiple proteins; this strategy achieved the retention of function, increased stability, and orientation control of the proteins in the fabricated particle.
The expression pattern was very much similar for 11 pairs of genes indicating retention of function.
This retention of function could aid horizontal gene transfer of mobile genetic elements containing ardA genes across species boundaries [39].
Thus, the reason for the conservation of Ser236 still remains unclear, though the explanation for its retention of function after replacement with alanine is now better understood.
In previous attempts at structural work [12,39], no assays to show retention of function in the purified material of any kind were carried out.
A distinction should of course be made between transfer of exRNA into a recipient cell – with retention of function such as miRNA-mediated regulation – and stimulation of signaling from outside the cell by exRNA.
One explanation is that the majority of MC2R mutations are missense mutations with some retention of function, and hence do not represent a human equivalent of an MC2R knockout.
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