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The retention of effect postintervention in individuals with CP is an important consideration for exercise prescription in order to periodise and plan the timing of future therapies.
Given that the main outcome measure, PHQ-9, has cut off points related to DSM IV depression conditions (e.g., dysthymia, major depression), we will be able to evaluate loss of benefit and retention of effect within the treatment group based on clinically relevant features.
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Follow-up will be performed at 6 and 12 months following intervention, to determine the retention of effects.
Retention of effects will be collected in the Waitlist group by an additional assessment at 60 weeks postrandomisation (T4; see figure 1).
Assessments will be performed at baseline (T1: 0–2 weeks pre BoNT-A injection/s), 10 12 weeks post BoNT-A (T2: on completion of the six week rehabilitation block, efficacy) and at 26 weeks post BoNT-A (T3) to determine medium-term retention of effects.
This study shows that ReST treatment delivered twice-weekly results in significant retention of treatment effects to four months post-treatment and generalization to untrained but related speech behaviors.
Importantly, for both types of training, the retention of the effects seems to depend on the frequency and continuity of training.
This indicates a retention of training effects that is equivalent to gaining back at least one or more years of natural disease progression.
Previous research has questioned the retention of intervention effects over time, especially with regards to attitudinal and behavioral change [ 28, 29].
High RF of polyhexamethylene guanidine phosphate and retention of bactericidal effects, even at 0.05%, support the use of polyhexamethylene guanidine phosphate as a biocide with sufficient anti-microbial activity against periopathogens.
Independent from the type of ataxia, training intensity in coordination exercises correlated significantly with differences in SARA scores after 1 year, indicating that retention of training effects depends crucially on continuous training [ 35].
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