Nanoscale drug delivery systems (NDDS) have shown great potential in tumor treatment due to its unique advantages, especially its unique enhanced permeability and retention effect (EPR) in solid tumors.
We also found that Evans Blue, a dye classically used to measure vascular permeability and to demonstrate the "enhanced permeability and retention (EPR) effect" in solid tumors, forms colloids that adsorb albumin, as opposed to older literature that suggested the reverse.
Furthermore, polymeric micelles appear to take advantage of the enhanced permeability and retention effect (EPR effect) in solid tumors to increase drug accumulation at the tumor sites.
Nanocarriers take advantages of the enhanced permeability and retention (EPR) to accumulate passively in solid tumors.
The formation of rapid microemulsion after reconstitution of solid SMEF indicates the retention of self-emulsifying properties in solid form and 3(c)).
A large amount of the suspended biomass could remain in the reactor by filtration through the nonwoven membrane and biofilms, resulting in improvement of the effluent quality and enhancement of the solid retention in the reactor.
The plasma concentration time profile indicates the retention of microemulsion properties of liquid SMEF in solid dosage form with improved bioavailability.
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Particles with a size of less than 400 nm present with enhanced permeability and retention effects, which are necessary characteristics for accumulation in solid tumor [25].
In an aqueous environment the copolymers form supramolecular structures and thus increase drug accumulation in solid tumours due to the EPR (enhanced permeability and retention) effect.
