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Moreover, drug retention in cell monolayers was significantly higher for NPs in comparison with the free drug.
The expression of V194D matrilin-3 consistently results in aggregation through non-native disulphide bonds and intracellular retention in cell and mouse models of MED (Fig. 6A and B, respectively) (12, 30, 35).
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Current oral cART regimens have several drawbacks including (1) challenges in patient adherence due to pill fatigue or side-effects, (2) the requirement of life-long daily drug intake, and (3) limited penetration and retention in cells within lymph nodes.
Although 18 F-FDG is useful for assessment of immediate delivery of cells and early fate of cells (approximately first few hours), it is not suited for in vivo cell tracking after 24 h post-injection due to its short half-life and poor retention in cells.
The interaction of this aldehyde with proteins increases retention in cells that express the enzyme.
3-BrPA causes ATP depletion, decreasing ABC transporter activity and drug efflux, therefore enhancing drug retention in cells producing preferential cell death in malignant cells.
Long label retention in cells may result from the presence of originally labeled cells that went out of the cell cycle shortly after label administration.
To study the mechanism of Ig light chain retention in cells following Hsp70 silencing, we investigated whether Hsp70 isoforms were involved in proteasomal degradation in MM cells.
Furthermore, their accumulation in the bioenvironment and retention in cells and tissues are arousing increasing worries about the potentially harmful side effects of these nanotechnologic products.
Higher circulating hepcidin is expected to lead to a greater decrease in the amount of FPN1 on erythroid precursors and thereby to increased iron retention in cells, which in turn will lead to an increase in the availability of iron to enhance hemoglobin synthesis.
Fates of these cells were established: retention in metaphase, cell death, progression through M phase generating more than two daughter cells or cell fusion during telophase or cytokinesis.
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