Highly significant, predictive relationships were found between the chromatographic retention constants and the bioactivity descriptors, which are assumed to account for drug absorption, distribution, elimination and toxicity (ADMETox) in humans.
Reversed-phase thin-layer chromatographic (RP TLC) retention constants for a newly designed series benzimidazole/benztriazole with expected biological activity were determined as parameters of their lipophilicity and this series was recognized as congeneric.
The bioactivity descriptors, which are assumed to predicted drug absorption, distribution, metabolism, elimination and toxicity (ADMETox) in humans, were correlated with retention constants and good statistical parameters were obtained.
Multiple regression analysis which was introduced suggested that the absorption through different epithelial membranes (intestinal, blood brain or erythrocyte membrane) and distribution process depend on retention constants (as measure of lipophilicty) and total polar surface area and molar weight/volume of the analyte.
An unexpected benefit of the program is worker retention — a constant headache when pickers can swap information via cellphones about better pay elsewhere.
The purpose of this study is to investigate the effect of controlled environmental conditions on moisture retention, dielectric constant (DC), compressive strength, shrinkage, water sorptivity index, rapid chloride migration test (RCMT), microscopical analysis (thin sections) and electrical resistivity.
After an initial rapid washout of approximately 50% of the radioactivity, retention remained constant for 3 h.
Peak D retention time remained constant from standard to sample.
The SP015A membrane had constant retention on phospholipids (70 77%).
The linear regions I and III characterize a stable process of deuterium implantation with a constant retention coefficient in the corresponding dose range.
