Sentence examples for retention binding from inspiring English sources

The potentially functional rs5855 SNP upstream of the PAM mRNA La protein nuclear retention binding site was identified using in silico inspection of 3′UTR SNPs.

With regard to this potential regulation by the La protein, we note that the 3′UTR of human PAM contains a SNP, rs5855 (A/G, G is the minor, but ancestral, allele), positioned 60 bp upstream of the La protein nuclear retention binding site.

While the bulk of acetylation and deacetylation is directed toward histones; numerous studies demonstrate transcription factors such as p53,, and the estrogen receptor (ERα),, are acetylated and deacetylated by HATs and HDACs, influencing their nuclear retention, protein binding, and DNA binding activity.

The R133C mutation has not previously been modelled in mice, but it has been proposed that its milder phenotype is due to retention of binding to 5-methylcytosine accompanied by loss of binding to hydroxymethylcytosine (hmC) (15).

The extent of kidney uptake and retention suggests binding of J591Cdia to PSMA expressed in the renal proximal tubules.

C3d facilitates antigen retention by binding to CD21/35 on FDCs, which do not efficiently endocytose antigen and may protect bound antigen from proteolysis, thus creating a depot effect.

We believe that this subtle retention reflects binding in the tumours.

A standard antigen selective ELISA was performed to assess retention of binding activity after temperature incubation.

In contrast, retention and binding of secreted APRIL by neutrophils has never been observed.

Despite a limited interspecies retention of binding sites, several biological features make sites more likely to be retained.

The strategy allows for the generation of a homogeneous ADC product via functional, antibody interchain disulfide-bridging that displays retention of binding to its target antigen.