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Downregulation of uPAR and cathepsin B also retarded nuclear translocation and interfered with DNA binding activity of CREB in both U251 and 5310 cells.
In this study, western blot analysis of cytoplasmic and nuclear fractions showed that uPAR and cathepsin B downregulation retarded the translocation of p-CREB in both U251 and 5310 cells.
Note the convention that positive V and Δ P both induce DNA translocation through the pore, while negative values retard translocation.
We believe that the finding that p-AKT binding to DRAM retards the translocation of DRAM to mitochondria is of considerable importance, as it links DRAM-mediated autophagic apoptosis to the PI3K/AKT pathway in hepatoma.
"Mentally retarded?
Retarded people.
Retarded potentials.
"He wasn't retarded.
Am I retarded?
and was mentally retarded.
Todd seems retarded.
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