Exposure can cause stunted growth, permanent mental retardation, speech impairment, hearing loss, reproductive problems, and kidney damage.
The potential dangers considered included death or neuro-developmental delay or disability such as motor deficit, delayed milestones, mental retardation, speech defects or deafness.
Further determination of the use of CMA testing for the evaluation of the child with growth retardation, speech delay, and other less well-studied indications is recommended, particularly by prospective studies and after-market analysis.
Patients exhibit mental retardation, delayed speech and language delay, epilepsy, extrapyramidal signs, and autistic behavior [ 8].
An X-linked disorder (Allan–Herndon Dudley syndrome) of childhood-onset, with psychomotor retardation including speech and developmental delay and spastic quadriplegia, is caused by defects in the MCT8 (SLC16A2) gene, encoding a membrane transporter.
In contrast, Angelman syndrome, which is caused by loss of maternal expression in the same genomic region, results in mental retardation, impaired speech, and an abnormally joyful demeanor (Peters, 2014).
It includes eight items based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria [ 23] and features delirium, including inattention, disorientation, hallucination-delusion psychosis, psychomotor agitation or retardation, inappropriate speech or mood, sleep/wake-cycle disturbances, and symptom fluctuation.
36 Later on, studies revealed a variety of symptoms in addition to the general characteristics of the OAV such as dysplastic ectopic, or bilobed caruncles, nasal sinus, nasal-ocular cleft, 37 ocular colobomas, 38 facial nerve paralysis and mental retardation, 39 speech impairment, and difficulties in feeding/eating.
This idea has some basis given the variability of the clinical phenotypes linked to NRXN1 deletions, which include autism, schizophrenia, mental retardation, and speech delay (Ching et al., 2010), with patient populations that have mixed genetic backgrounds compared with repeatedly backcrossed mouse strains.
The ICDSC consists of eight items based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria and features of delirium, including inattention, disorientation, hallucination (delusion psychosis), psychomotor agitation or retardation, inappropriate speech or mood, sleep/wake cycle disturbances, and symptom fluctuation.
A study published in the journal Pediatrics in 2005 analyzed special education data from across the country and found that the growing prevalence of autism diagnoses did not correlate with a decrease in the rate of mental retardation and speech-language delays.
