Ms. Vargha's sister received a number of shifting diagnoses over the years, including autism-related disorders, mild mental retardation, post-traumatic stress, bipolar disorder and schizophrenia.
Differentially expressed genes within these pathways were subsequently investigated for any mammalian phenotypes associated with maternal performance, such as post-natal growth retardation, post-natal lethality, mammary gland development and maternal/paternal imprinting by data mining the Mouse Genome informatics (MGI) database [ 61].
Here we describe a method of superficial lamellar dissection of grade-1 limbal dermoids combined with application of fibrin glue-assisted multilayer amniotic membrane transplantation (AmnioGraftTM, Bio-Tissue Inc, Miami, FL, USA) as a biological substrate for corneal stromal growth, re-epithelization, retardation in post-operative scar formation, and reduction of post-operative pain.
Placenta pathology was associated with decreased fetal viability, intra-uterine growth retardation, gross post-natal growth impairment and increased disease severity in pregnant females.
Inheritance of two maternal copies of human chromosome 14q32.2 (Temple syndrome) causes severe foetal growth retardation and post-natal failure to thrive.
We observed three key phenotypes in TGPAT mice as a consequence of this transgene insertion: embryonic growth retardation, reduced post-natal growth rate and impaired adult glucose homeostasis.
The results show that the crack opening loads and effective stress intensity factors at the overload event are proportional to the magnitude of the overload and that period of post-overload retardation of crack growth is also proportional to the magnitude of the overload.
In addition, the percentage of infants discharged with post-natal retardation at 36 weeks of gestational age was significantly lower in the intervention group.
Subjects 1, 2, and 4 had similar clinical histories, including severe psychomotor retardation, feeding problems, severe post-natal growth retardation, arched eyebrows, anteverted nares, and ulnar deviation of the hands (Table 1, Figure 1), which are features partially shared with Cornelia de Lange Syndrome (CdLS) and BOS, but they did not have the trigonocephaly that is characteristic of BOS.
Lmna-null mice show post-natal growth retardation with weight ∼50% of their wild-type littermates at 28 days of age [14].
It is noteworthy that deficiency of 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme in cholesterol biosynthesis, is the genetic cause of Smith-Lemli-Opitz syndrome (SLOS) which is an autosomal recessive disorder characterized by pre- and post-natal growth retardation, distinct facial anomalies, microcephaly, and mental retardation [73], [74].
