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The exclusion criteria of the ADS study included mental retardation, age under 13 or over 19 years, or insufficient knowledge of the Finnish language.
The exclusion criteria for all participants were: history of moderate/severe head injury, neurological disorder, mental retardation, age outside the range of 18-65 yeand, anotnot speaking a Scandinavian language.
Patients were excluded from the study if they met any of the following criteria: organic central nervous system disorder (e.g., epilepsy, traumatic brain injury, infectious or toxic cerebrovascular disease), mental retardation, age less than 18 years or greater than 40 years, or inadequate knowledge of the German language.
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Over the course of seven years we investigated retardation of aging with a mitochondria-targeted antioxidant SkQ1 [10-(6'-plastoquinonyl) decyltriphenylphosphonium].
Rapamycin-treated mice also show retardation of age-related deficits in liver, tendon, heart, endometrium, and adrenal tissues, and delay in the age-sensitive decline in spontaneous activity (Wilkinson et al., 2012).
Retardation of aging processes is a plausible approach to delaying the onset or slowing the progression of common neurodegenerative disorders.
Indeed, significant effort and resources may be wasted if any model subsequently shows no repeatable retardation in aging.
On the other side, it remains enigmatic which components of reproductive activity actually trigger the apparent retardation of ageing induced by attainment of breeder status.
Nor is this a generalised retardation of ageing since longevity appears unaltered in 11β-HSD1 deficient mice.
This 'homogenization' results in a retardation of aging of the HSC population.
CR may play a role in the retardation of aging by decreasing mitochondrial ROS production.
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