Sentence examples for retains wild type from inspiring English sources

When introduced into human cells, the viral DNA sequence of this construct, TowneBAC, produces infectious progeny and retains wild type growth characteristic in vitro.

Accordingly, a mutant version of Srs2 that retains wild type levels of ATPase and helicase activities, but fails to interact with Rad51 is compromised for its anti-recombinase function [30].

These findings suggest that the combined use of ABL kinase inhibitor and DNA damaging drug in chemotherapy against tumors retaining wild type p53 should be carefully designed.

Mutations within the p53 gene, leading to the loss of p53 activity, are found in about half of all human cancers, while many of the tumors that retain wild type p53 carry mutations in the pathways that allow full activation of p53.

As expected, Sec24C morphants retained wild type appearance throughout the observation period, whereas Sec24D morphants showed the first defects shortly after the 48 hpf time mark.

The Arg101→Asp and Arg115→His double mutant, however, is the only variant thus far proven to retain wild type or better lytic activity in the absence of inhibitory biopolymers (Fig. 1).

The Dmp1+/- tumors often retain wild type allele of DMP1, thus DMP1 is haplo-insufficient for tumor suppression [ 37].

Interestingly, patients with tumours that show elevated PLK1 expression, but retain wild type TP53, have a relatively favourable outcome.

In addition, the over-expression of MDM2 and/or MDMX is generally accepted to correlate with retained wild type P53 [ 27].

Furthermore, the retained wild type matrilin-3 was not present as high molecular weight aggregates in the Comp DelD469 chondrocytes (not shown).

Mutant strains containing disruptions in the genes encoding the member of the AH superfamily and the PdxA-like protein retained wild type growth on l-lyxonate.