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Here we report the cloning of the genes encoding the variable regions of CG10 heavy and light chains and demonstrate that when attached to human IgG1 Fc, the single chain Fv of CG10 retains the binding properties of the original mouse antibody.
This structure still retains the binding properties of classical antibody.
Here, we show that VCN retains the binding profile of CN yet it engages integrins in a unique manner.
To further study the cytolytic mechanism of this toxin, we have cloned and produced a recombinant protein fully active on target red blood cells and which retains the binding to GM2.
Taken together, the binding studies, along with the previously described in vitro and in vivo protection analyses, indicate that the chimeric form of the #29 antibody retains the binding properties of its parental murine antibody.
The mutant NBS1 protein retains the binding ability and effectively suppresses the expression level of the MRN in infected cells.
Similar(51)
The results showed that the Ile529Ala and Asn560Ala mutants retained the binding activity to 8C11, but they can't bind to 8H3 with the presence of 8C11 (Fig. 2B), suggesting that the epitope of 8C11 was retained, but the epitope of 8H3 was damaged in mutants Ile529Ala and Asn560Ala.
E. coli transformed with appropriate plasmid vectors express human β1 and β2-adrenergic receptors that retain the binding properties of the corresponding receptors in mammalian tissues.
hu5A8 is a molecularly engineered human IgG4 antibody retaining the binding and functional properties of the murine version of 5A8 (mu5A8).
Engineered monovalent antibody/ligand pairs that retain the binding specificity of the antibody, but do not dissociate, are promising components of new delivery systems.
Single-chain variable fragment (scFv) antibodies retain the binding specificity of antibodies and, when genetically manipulated to create high-diversity libraries, allow in vitro selection against peptides.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com