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As compared to Euclidean distance, Sorensen distance retains sensitivity in more heterogeneous data sets and gives less weight to outliers.
This work proposes a method of implementing priors that on one hand reflects the belief concerning the typical situation and on the other retains sensitivity to anomalies of the prescribed type.
Analysis of these DAT mutants reveals that inserting a tetraCys site into DAT extracellular loop 2 (EL2) is well tolerated by DAT, and yields a functional transporter that retains sensitivity to PKC activation, whereas insertion of tetraCys into either extracellular loop 3 or 4 (EL4, EL4) perturbs DAT biosynthesis and trafficking to the cell surface.
This is assumed to be a milder mutation that retains sensitivity to diazoxide.
Although MPN colony formation is an erythropoietin-independent phenomenon, it retains sensitivity to erythropoietin-signaling pathway inhibitors, including the janus kinase 2 (JAK2) inhibitor, AG490.
In blast crisis of CML and in de novo Ph+ ALL, BCR-ABL retains sensitivity to imatinib, but additional genetic abnormalities conferring drug resistance are common.
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Basic research investigating the efficacy of trastuzumab-DM1 for HER2-positive breast cancer cell lines has found that trastuzumab-resistant cells retain sensitivity to trastuzumab-DM1 [7].
The eyes are regressed, but retain sensitivity to light.
Our data show that although ESSC are resistant to standard cytotoxic agents, they retain sensitivity to YK-4-279.
Ewing's sarcoma contains an ALDHhigh stem-like population of chemotherapy-resistant cells that retain sensitivity to EWS-FLI1 inhibition.
We then demonstrated that these cells express EWS-FLI1 and that, in contrast to cytotoxic drugs, they retain sensitivity to the small molecule inhibitor YK-4-279 YK-4-279 YK-4-279
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com