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Thus, although the amount of enzyme decreases significantly in the tissues, the enzyme that retains normal activity can contribute significantly to the amount of residual activity in these mice.
Given the large number of single amino acid changes along the length of NEMO that are associated with human disease, we find it surprising that a NEMO protein with eight scattered amino acid changes (as in L107C)) retains normal activity.
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Only Δ26 FMO variants retained normal activity, increased the yield of cytosolic rF2 and decreased protein aggregation.
Monocytes and peritoneal macrophages exhibited reduced anticryptococcal activity 14 days after infection with HIVBal but retained normal activity when infected with HIVIIIB.
Thus, siRNAs from FOP patients have been utilized to retain normal activity of BMP [ 37, 38].
We previously reported that chronically hypoxic flies retain normal activities but age at a faster rate than normoxic flies.
The mutant protein is stable in vivo and retains normal kinase activity in vitro (Supplementary Figure S8).
These studies showed that the 6M protein retained suppressor activity comparable with that of the protein without caspase site mutations; this indicates that the 6M protein retains normal Ataxin-3 activity and thus is likely properly folded.
This showed that the 6M protein retains normal Ataxin-3 activity.
Alveolar macrophages retained normal anticryptococcal activity whether infected with HIVBal or HIVIIIB.
Thus, negatively isolated neutrophils retain normal functional activity in vivo.
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