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The α2Pβ2S retains normal tetrameric structure (α2β2) of human Hb and an O2 affinity comparable to that of HbS in 50 mM Hepes buffer; but, its O2 affinity is slightly higher than that of HbS in the presence of allosteric effectors (chloride, DPG and phosphate).
We have established an immortal human NSC line (IhNSC) cultured at 5% oxygen that retains normal hNSC features such as proliferation, self-renewal and multipotency [18].
For example, the R2 allele contains an approximately 2kb deletion of the tandem DNA repeats but, since Region 2 is roughly 2kb, insertion of Region 2 retains normal sequence spacing.
Thus, although the amount of enzyme decreases significantly in the tissues, the enzyme that retains normal activity can contribute significantly to the amount of residual activity in these mice.
We further show that the atypical antipsychotic drug clozapine, but not the typical antipsychotic haloperidol nor an experimental glutamate receptor 2/3 agonist, inhibits ketamine's effects and retains normal fear processing in the amygdala at a neurochemical level, despite the observation that fear-related behavior is still inhibited due to ketamine administration.
In parallel, IN-V5 carrying a D116G mutation at the IN catalytic sites was also tested, since HIV-1 with a D116G variant of IN is defective for proviral integration but retains normal level of cDNA synthesis (reverse transcription) activity [11], [29], [30].
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Mice lacking Myog fed normally, exhibited increased cage activity by 1 year of age, and retained normal survival over a 2-year period of observation.
An alloy of zinc containing 22 percent aluminum has commercial potential by virtue of its superplastic properties that is, its ability to be formed as readily as a plastic at elevated temperatures while retaining normal metal properties at room temperature.
This NP therefore produces short cells that retain normal length and width proportions.
BCECs can survive, grow and retain normal characteristics in the H1F15 hydrogel with P-PRP.
Majority of heart failure patients who suffer from diastolic dysfunction retain normal systolic pump action.
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